• DNA clamp loader activity
• double-stranded DNA binding
• protein binding
• ATP binding
• enzyme activator activity
• protein domain specific binding
• sequence-specific DNA binding
Компонент клетки
• nucleus
• nucleoplasm
• DNA replication factor C complex
• nucleolus
• Golgi apparatus
• cell junction
• extracellular vesicular exosome
Биологический процесс
• negative regulation of transcription from RNA polymerase II promoter
• mitotic cell cycle
• telomere maintenance via recombination
• telomere maintenance
• ATP catabolic process
• DNA-dependent DNA replication
• DNA strand elongation involved in DNA replication
• DNA repair
• transcription-coupled nucleotide-excision repair
• nucleotide-excision repair
• nucleotide-excision repair, DNA gap filling
• transcription, DNA-templated
• telomere maintenance via telomerase
• telomere maintenance via semi-conservative replication
• positive regulation of catalytic activity
• positive regulation of transcription, DNA-templated
Белок, кодируемый этим геном является большой субъединицей фактора репликации С, который является субъединицей пяти аксессуарных белков ДНК-полимеразы. Фактор репликации С является ДНК-зависимой АТФазой, что требуется для эукариотическойрепликации и репарацииДНК. Белок действует в качестве активатора ДНК-полимераз, связывается с 3'-концами праймеров, а также способствует скоординированному синтезу обеих нитей. Он также может играть определенную роль в стабильности теломеров. [2]
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